Leveraging Machine Learning for a Comprehensive Assessment of PFAS Nephrotoxicity

Leveraging Machine Learning for a Comprehensive Assessment of PFAS
Nephrotoxicity

Volume 9, Issue 3, Page No 62-71, 2024

Author’s Name: Anirudh Mazumder, Kapil Panda

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University of North Texas, Texas Academy of Mathematics and Science, Denton, 76203, United States of America

^a)whom correspondence should be addressed. E-mail: kapilpanda@my.unt.edu

Adv. Sci. Technol. Eng. Syst. J. 9(3), 62-71(2024); DOI: 10.25046/aj090306

Keywords: Machine Learning, Kidneys, Polyfluoro-Alkyl Substances, Toxicokinetics

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Abstract

Polyfluoroalkyl substances (PFAS) are persistent chemicals that accumulate in the body and environment. Although recent studies have indicated that PFAS may disrupt kidney function, the underlying mechanisms and overall effects on the organ remain unclear. Therefore, this study aims to elucidate the impact of PFAS on kidney health using machine learning techniques. Utilizing a dataset containing PFAS chemical features and kidney parameters, dimensionality reduction and clustering were performed to identify patterns. Machine learning models, including XGBoost classifier, regressor, and Random Forest regressor, were then developed to predict kidney type from PFAS descriptors, estimate PFAS accumulation in the body, and predict the ratio of glomerular surface area to proximal tubule volume, which indicates kidney filtration efficiency. The kidney type classifier achieved 100% accuracy, confirming that PFAS exposure alters kidney morphology. The PFAS accumulation model attained an R2 of 1.00, providing a tool to identify at-risk individuals. The ratio prediction model reached an R2 of 1.00, offering insights into PFAS effects on kidney function. Furthermore, PFAS descriptors and anatomical variables were identified through analyses using feature importance, demonstrating discernible links between PFAS and kidney health, offering further biological significance. Overall, this study can significantly contribute to the current findings on the effect of PFAS while offering machine learning as a contributive tool for similar studies.

Received: 04 March 2024, Revised: 18 May 2024, Accepted: 19 May 2024, Published Online: 12 June 2024

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